Effects of Methadone : More Than For Methadone Treatment

What Are The Effects of Methadone ?

Effects of Methadone

Effects of Methadone

There are mainly two groups of people who need to know the effects of methadone.  The person who is being treated for pain with methadone is one.  The other is the opioid addicted individual who wants information on methadone treatment. It is important to realize that the opioid dependent person is not longer limited to the stereotypical heroin addict.

Over the last decade, there has been a rise in the use of oxycontin in addition to methadone for the treatment of various forms of pain.  Many people who never had an addiction started these medications through their primary care doctor for a legitimate reason such as a broken leg or perhaps severe back pain. Some are more susceptible to the addictive effects of methadone.

Although getting an addictive disorder is on of the effects of methadone, when use as directed under the care of a physician, the risk of addiction to pain medications is low (4-5%). There are estimated to be about 30 million patients in the United States so even this small percentage of abusers is a large number. There has been a more recent article indicating up to 1/3 of people being treatment for non-cancer pain on a chronic basis get addicted to opioid medications.  Apparently, this was in the July 2011 issue of the Journal for Addictive Diseases and I have not reviewed the actual article. Here is one link.

There are, however, a much larger number of individuals who are abusing the medication through non-medical sources. Most people abusing opioids are getting the medication through family or friends rather through “drug dealers.” They may be using is for recreational use.  There are many others who are at higher risk to having an one of the addictive effects of methadone: especially those who are  mentally ill and those with an existing addiction,

Effects of Methadone

  • Treatment of Pain : Excellent for acute (sudden) pain. Can work well for chronic (long-term) pain, however, the effectiveness for long-term pain is being questioned as compared to other pain relieving medication.  The exception is cancer pain.
  • Increase in energy: Patient report to me lower doses give them energy
  • Euphoria: People describe a “better than sex” feeling.  A feeling of falling backward, being half dead and alive and sleepy.
  • Reduce or stop coughing
  • Reduce or stop diarrhea
  • Treatment of Opioid Addiction (such as methadone maintenance)

Side Effects of Methadone : Go to my article or See Below

Methadone Side Effects List :

  • nausea
  • decreased libido
  • urination problems
  • decreased appetite
  • sedation
  • weight gain
  • flushing
  • abdominal pain
  • constipation
  • vision changes
  • mood swings
  • swelling of limbs
  • weakness
  • difficulty with sleep
  • vomiting
  • missed menstrual periods

Serious Side Effects of Methadone : Call Your Doctor Immediately:

  • rash
  • seizures
  • itching


  • irregular heartbeat and death

Summary of Effects of Methadone

Methadone is a very good pain reliever and has some other medical uses such as for cough, diarrhea, and the treatment of opioid addiction. Although it can be safely used under proper medical supervision, there is a real risk of addiction. The risk of addiction is more for those with mental illness, a genetic predisposition, and current addicts. Patients taking methadone should be aware of the side effects of methadone to know what to discuss with their doctor.

Other Resourses Related to the Effects of Methadone :

National Pain Foundation FAQ on Opioids

US Department Of Health and Human Services : Research on Prescription Drug Abuse

History of Methadone

Methadone Treatment Center Directory and Suboxone Doctor Directory

Dr. Rich is a Board Certified Psychiatrist with licenses in Texas and Hawaii. He specializes in the treatment of opioid addiction with buprenorphine and runs a FREE locator service to find Methadone Treatment including Suboxone treatment for opioid addiction. Find a Suboxone Doctor in your area.
Dr. Rich has written more articles on the cost of oxycontin, buprenorphine (Suboxone) including frequently asked questions and a recent post : Signs of Painkiller Addiction

Methadone Overdose : Signs, Symptoms, and What To Do

Methadone Overdose : Yes It Kills Opioid Addicts

Methadone Overdose

Methadone Overdose

Methadone Overdose has been on the rise. According the the US Government Accountability Office in 2009, methadone prescriptions for for the treatment ofpain grew from about 531,000 in 1998 to about 4.1 million in 2006.  The Centers for Disease Control has shown that only car accidents lead drug overdoses, (including prescriptions) in unintentional injury deaths in the USA. Methadone leads other narcotics such as hydrocodone, oxycodone, codeine, and fentanyl in the number of deaths per year.  In 2005 there were 4,462 methadone related deaths.

Methadone is listed as a Schedule II Controlled Substance by the DEA.  This means the drugs in this schedule have a high potential for abuse. They may also lead to severe psychological or physical dependence.  Oxycodone, methadone, and morphine are included in this list among others. Here is a more complete list of schedule II drugs.

Methadone Overdose : Why Is It Increasing Now?

Starting around 2000, there was a push to make sure pain patients were receiving adequate pain relief. When methadone is used for the treatment of pain, it is not under the same restrictions as when it is given in an Opioid Treatment Program. In other words, it is easier for doctors to prescribe it for pain.

As a result, there was an increase in the number of methadone prescriptions since 2000. In 2007, many doctors became concerned with the addictive problems with oxycontin and began using more methadone to treat pain. With more availability of methadone came more misuse and diversion of the drug. The number of people with a methadone overdose has increased, in part, to this increase in availability and diversion.

Here are some more causes of methadone overdose:

  • Injected (more potent) too much
  • Person is not accustomed to starting methadone and initial dose too much
  • Dose of the methadone is increased too fast
  • Methadone was combined with other sedating and interacting drugs.
  • Suicide attempt

Methadone Overdose : The Signs and Symptoms

  • Sedation: This can range from being groggy, dizzy, disoriented,  to being limp and comatose.
  • Breathing: More shallow or slow than usual
  • Vomiting
  • Unable to wake up or arouse
  • Pupils are pinpoint
  • Heartbeat may be irregular and/or decreased
  • Speech may be slurred
  • Lack of oxygen: fingertips and/or lips turning blue
  • Skin may be cold and clammy
  • muscle twitching

“An often unrecognized symptom of methadone overmedication is unusual feelings of excess energy with or without euphoria. As methadone levels drop the other signs/symptoms may emerge.” Source.

Methadone Overdose : What To Do

Remember, people usually die from methadone overdose by stopping breathing.  Time is important and breathing can stop suddenly.

Call 911

Always call 911 first if the person cannot be woken up. You should also be aware of the a national number:

National Poison Control Center  1-800-222-1222

The next things during a suspected or know methadone overdose (or any opioid overdose)

  • Be prepared to perform CPR if they stop breathing
  • Don’t leave the person alone, the could stop breathing
  • Try to determine what they took, how much, and when. Where there other drugs used
  • Don’t try to stand the person up or move them around unless you have training. This could lead to trauma and vomiting among other things.
  • Don’t make them vomit: it could cause them to choke on the vomit or breathe it into their lungs

Summary of Methadone Overdose

The number of people having a methadone overdose has been on the rise during the last decade. This is most likely due to an increase in the availability and diversion of methadone.  There are typical signs and symptoms of a methadone overdose that are the same for any opioid overdose. You primarily need to worry about the person stopping breathing. Be prepared to do CPR and always call 911 immediately.

More resources for Methadone Overdose :

Methadone Associated Overdose Deaths : USGAO 2009

NY Times Article on Methadone Ovedose


Suboxone Treatment Directory And Methadone Treatment Directory

Dr. Rich is a Board Certified Psychiatrist with licenses in Texas and Hawaii. He specializes in the treatment of opioid addiction with buprenorphine and runs a FREE locator service to find Methadone Treatment including Suboxone treatment of oxycontin addiction. Suboxone Doctor in your area.
Dr. Rich has written more articles on the cost of oxycontin, buprenorphine (Suboxone) including frequently asked questions and a recent post : Suboxone Cost : Will Medicare and Medicaid Cover Treatment ?