Swollen ankles…sore joints! Help Please

Author: hatmaker510

Posted: Wed Nov 30, 2011 8:10 am

Other people on this forum have experienced some edema in the beginning of their sub treatment. If I recall correctly, theirs subsided eventually. But that said, usually when something is related to a side effect of sub, it’s when one is one a much higher dose of sub. Now that’s not to say that at your very low dose that you can’t be having side effects still.

I do agree with Oxy-Ed that you might want to get it checked out w/ your doctor though. Just to be on the safe side.

very concerned

Author: hatmaker510

Posted: Wed Nov 30, 2011 8:24 am

Oxy-Ed wrote:
Brushing your teeth won’t affect the absorption. If he truly keeps the sub under his tongue for the 10 minutes then brushing after won’t reverse what has already dissolved. If he is swallowing without saying so then he won’t be getting the right amount of med. After 10 minutes under the tongue, your body has absorbed all it will absorb. Some people (myself included) like to keep it under the tongue until your left with nothing but pure saliva. But after the 10 minutes or until the whole pill is dissolved, your body has already absorbed all it will. The reason why we dissolve under the tongue is we have capillaries under the tongue and the drug gets absorbed into these capillaries which lead the drug to your blood system. So brushing your teeth wouldn’t change what’s already in your blood.

Actually, after the tablet or film dissolves, there IS leftover medication on the mucous membranes that can still absorb. So yes, drinking, eating, and brushing teeth right away will remove some more of the medication that can still get into one’s system. (BTW, all this info is from Dr. Junig – who’s pretty much considered a suboxone expert). Also, there’s nothing special about the area under the tongue. ANY of the mucous membranes in the mouth can absorb the medication in the tablet or the film. Do a search for Dr. Junig’s "maximum absorption" method on his Suboxone TalkZone blog (there’s a link at the top of this page) and it will explain much of this.

Just wanted to clarify.

Generic Suboxone film?

Author: tearj3rker

Posted: Wed Nov 30, 2011 8:25 am

I had no idea about this, but it’s very interesting.

This company BEMA has a "proprietary technology" that seems to be a lot like Suboxone film. They’ve been doing studies in comparing their buprenorphine / naloxone product with Suboxone, with apparent success.

Check it out:

BEMA Buprenorphine/Naloxone

BioDelivery Sciences is developing BEMA Buprenorphine/Naloxone for the treatment of opioid dependence. The product will combine a "high dose" of buprenorphine along with an abuse deterrent agent, naloxone. Preliminary pharmacokinetic studies have demonstrated the ability of the BEMA technology to deliver the high doses of buprenorphine necessary for the treatment of opioid dependence.

A BEMA Buprenorphine/Naloxone product would provide BDSI with an opportunity to compete in a rapidly growing opioid dependence market. Buprenorphine is widely used in the treatment of opioid dependence and is marketed as Suboxone® (buprenorphine/naloxone) and Subutex® (buprenorphine). Accordingly to Wolters Kluwer, U.S. sales of buprenorphine containing products for the treatment of opioid dependence exceeded $1 billion in 2010. Initial pharmacokinetic studies have demonstrated the ability of the BEMA technology to deliver doses of buprenorphine needed for the treatment of opioid dependence.



Positive results from BDSI’s BEMA Buprenorphine/Naloxone formulation Phase 1 study on opioid dependence

BioDelivery Sciences International, Inc. (Nasdaq: BDSI) announced positive preliminary results from its Phase 1 study assessing the pharmacokinetics of a BEMA Buprenorphine/Naloxone formulation. BDSI is seeking to develop and commercialize a high dose formulation of buprenorphine combined with naloxone (abuse deterrent agent) for the treatment of opioid dependence.

This study assessed buprenorphine and naloxone absorption profiles from BDSI’s BioErodible MucoAdhesive (BEMA) formulation of buprenorphine/naloxone versus the FDA approved and currently marketed opioid dependence product, Suboxone. Results of the study demonstrated the ability of the BEMA formulation to meet the key pharmacokinetic goal of delivering plasma concentrations of buprenorphine in the range needed to treat opioid dependence while minimizing the exposure of naloxone.

"We are pleased with the results of this study as they are consistent with our expectations and allow us to now optimize our BEMA Buprenorphine/Naloxone formulation prior to conducting the pivotal bioequivalence study," stated Dr. Andrew Finn, Executive Vice President of Product Development at BDSI. "We expect to initiate the pivotal bioequivalence trial in December of this year with results expected during the first quarter of 2012. If the results from this pivotal study are positive, we could be in a position to submit a New Drug Application (NDA) for BEMA Buprenorphine/Naloxone in the second half of 2012."

When I first saw the picture, I got all excited thinking it was a Suboxone patch. But I’ll probably have to wait for that one.

Very confused please help me ladies!!!!

Author: Breezy_Ann

Posted: Wed Nov 30, 2011 8:49 am

Hi, I too am sorry you are having a hard time. I have never had a pregnancy test done by my sub Dr. I agree with most of your plan. You need to protect yourself and your baby so I too would go see a sub Dr to get on sub. Most people don’t even know that they are pregnant at 5 weeks, so even if he found out you could say you didn’t know and then explain why you need his help for the safety of both you and baby.

The part I don’t agree with is to just see him to get enough until you can get more on the street. What happens when your connection runs out again? Stopping sub cold turkey (especially in the 1st trimester) can be dangerous for your baby and could even cause a miscarriage. I would keep going to the sub Dr and after around 2 months I would tell them you discovered you were pregnant. I can’t imagine a dr stopping their treatment because you discovered being pregnant while already being treated. I think your running into the difficulty of finding a Dr because you are not legally on sub. Except for one post, I have never heard of a dr cutting their patient off because they became pregnant during treatment.

This is just what I would do in your shoes. I had all my children prior to becoming addicted and getting on sub. I feel so bad for the women that have to go thru a pregnancy while on sub. Pregnancy is supposed to be a joyous time and because of a lot of Drs bias, sub moms have to deal with a lot of stress and worry. I really hope this all works out with this Dr and you can relax and enjoy your pregnancy!


Author: tearj3rker

Posted: Wed Nov 30, 2011 9:05 am

I think it’s chemically similar to certain opioids. It’s definitely synthetic. But the difference is that, because of its shape, it doesn’t activate the receptors at all.

It woulda come from a laboratory. Some chemist was probably looking for a new opioid, synthesized naltrexone, realised it kicked other opioids off the receptors.. then he told his boss, and his boss probably thought "at least it does something. Maybe we could come up with a use for it?"

Stabelizing question…Day 14!!

Author: johnboy

Posted: Wed Nov 30, 2011 9:12 am

Hi kellykins wellcome to the Forum". i have to disagree with the 16mg limit. us with fast metabolism drugs go through us faster’ . the 2 dose per day also.
i have been on 22mg for a long time" and my doc is keeping me there. if i was below 16mg then i would be in high’er
risk, due to my other illness’s and addictions. some docs ;like my doc is aware of my pain/depression/ mood/addiction/cravings/metabolism/ and just me as my self. some times i am pist off at my doc for the wrong meds,
but when he finds the right one it works. he is a shrink, and understands my problems more than my medical doc.

Reckitt admit that Suboxone can be injected

Author: sweet16

Posted: Wed Nov 30, 2011 10:13 am

I stand corrected. Fair enough. I know sub is a very complex medication. There are so many variables and unknowns. I used to be angry for not being able to quit ASAP, now however, I’m glad for the time I have been on sub for it really has allowed me to take a good look at my life, the choices I’ve made and the choices I still have. All in all, another experience in life, one I may choose to not ever repeat(along with many other choices past) thank you for your opinion, I value everyone’s right to their own opinion & choices. Blessings to all.

This Angers Me

Author: Breezy_Ann

Posted: Wed Nov 30, 2011 10:17 am

I have a bit if both take on the subject. I do not think there should be a legal mandate that anyone on sub must seek therapy or counseling. However I do believe each Dr should have the power to run their practice as they see fit. If a sub Dr requires meetings, counseling or whatever than I am perfectly fine with that. If the patient doesn’t believe they need these things and does not want to participate then they can seek out a dr without these requirements.

These types of decisions should be left up to each individual Dr, not forced upon them. There are so many different levels and components to addiction and to force the same treatment on all of us makes no sense to me. We all heal in our own ways and should be treated on an individual basis.

Just my take on the subject.