CONCLUSIONS: It is difficult to draw conclusions on the basis of two trials with few participants. Furthermore, the two studies included did not consider the efficacy of methadone that is still the most frequent drug utilised for the treatment of opioid withdrawal. One possible reason for the lack of evidence could be the difficulty in conducting trials with young people due to practical and ethical reasons.
PMID: 24777492 [PubMed – as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

CONCLUSIONS: It is difficult to draw conclusions on the basis of two trials with few participants. Furthermore, the two studies included did not consider the efficacy of methadone that is still the most frequent drug utilised for the treatment of opioid withdrawal. One possible reason for the lack of evidence could be the difficulty in conducting trials with young people due to practical and ethical reasons.
PMID: 24777492 [PubMed – as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Question Question: In the treatment of opioid dependence, does the addition of behavioural treatment to buprenorphine reduce opioid use compared with buprenorphine alone? Patients: In total, 202 people meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revised (DSM-IV-TR) criteria for opioid dependence. Participants had to have good general medical and psychiatric health, no sensitivity to buprenorphine or naloxone, and no dependence on alcohol, benzodiazepines or any other drug. Setting: Outpatient clinical research centre in Los Angeles, California, USA. Intervention: In total, 16 weeks of buprenorphine with medical management plus either cognitive behavioural therapy (CBT, n=53), contingency management (CM, n=49), both CBT and CM (CBT+CM, n=49) or no b…

Question Question: In the treatment of opioid dependence, does the addition of behavioural treatment to buprenorphine reduce opioid use compared with buprenorphine alone? Patients: In total, 202 people meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revised (DSM-IV-TR) criteria for opioid dependence. Participants had to have good general medical and psychiatric health, no sensitivity to buprenorphine or naloxone, and no dependence on alcohol, benzodiazepines or any other drug. Setting: Outpatient clinical research centre in Los Angeles, California, USA. Intervention: In total, 16 weeks of buprenorphine with medical management plus either cognitive behavioural therapy (CBT, n=53), contingency management (CM, n=49), both CBT and CM (CBT+CM, n=49) or no b…

In conclusion, differences in respiratory effects between BUP/NLX and BUP are only significant in combination with DZP, with increased depression in naive rats but reduced depression in in BUP-tolerant rats. However, BUP/NLX benefits in humans remain to be determined.
PMID: 24769261 [PubMed – as supplied by publisher] (Source: Toxicology Letters)

In conclusion, differences in respiratory effects between BUP/NLX and BUP are only significant in combination with DZP, with increased depression in naive rats but reduced depression in in BUP-tolerant rats. However, BUP/NLX benefits in humans remain to be determined.
PMID: 24769261 [PubMed – as supplied by publisher] (Source: Toxicology Letters)

Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, … (Source: SafetyLit: All (Unduplicated))

Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, … (Source: SafetyLit: All (Unduplicated))

Suboxone has become a popular medication to use in detox from alcohol and other opiate addictions.(PRWeb March 14, 2014)Read the full story at http://www.prweb.com/releases/2014/03/prweb11671625.htm (Source: PRWeb: Medical Pharmaceuticals)

Suboxone has become a popular medication to use in detox from alcohol and other opiate addictions.(PRWeb March 14, 2014)Read the full story at http://www.prweb.com/releases/2014/03/prweb11671625.htm (Source: PRWeb: Medical Pharmaceuticals)