My SWITCH

Author: Bboy42287

Posted: Wed Nov 28, 2012 3:35 pm

Goinstrong wrote:
Hi Bboy…That is just great to hear how well you are doing!! I’ve been super busy lately and
haven’t been on the forum much. Maybe 2x a week? So I missed your posts! But I’m all caught up
again! Sounds like your life is pretty much riht where you want it right now. It sounds like things
couldn’t be better! I’m looking forward to cuttin down a tree this year too!
Last year the little guy was too young, but this year at Christmas, I cannot wait to see his little
face with the tree and lights, and all the decorations! I go ALL OUT!!!!
Like Orange Doll said, don’t worry about the dose so much. It IS just a number.
You are so smart when it comes to all of this, you’ll know what to do when the time
comes to adjust your dose one way or the other!

Well I was just checking in and seeing how you are! If I don’t talk to you beforehand, have
a happy Thanksgiving!!! Take Care~

Ive really been slacking on the forum of late cityman ill def reply to your post asap when im not on my phone lost post are a bitch to type up.

Thank you so much kelly for checking in you truly are one of the most kind hearted people on here. I bet your going to have a blast this Xmas with your lil guy i cant wait till the day i get to experience that feeling of sharing xmas for the first time once he or she could understand it. But hope all is well ill shoot you a pm to see how your doing when i get a chance.

Interesting article from Dr. J regarding tolerance

Author: welly321

Posted: Wed Nov 28, 2012 6:45 pm

Heres my thoughts. There are two major benefits to subs. Maintaining the physical side of addiction and also healing the mental side. When your taking suboxone as prescribed and staying away from old connects, the mental part of the addiciton is in remission. Obviously the physical part is still there. If someone on vicodin has such a crazy mental addiction that there willing to INCREASE the physical part just to fix the mental part then so be it. Let them do it. Its there choice. The prescribing dr should definitely explain that they will be increasing there physical addiction to opiates.

I mean to that person that said there tolerance was through the roof and they had to take 6 vics just to function. Lets just say that during my heroin use once i took 10 vicodin 7.5s and i was still sick. Even with this crazy tolerance, 8mg of sub is enough to keep me well. So using 8mg would increase your tolerance. If your ok with that then thats fine, its just doctors should be making the patients aware that the sub WILL be making there physical addiction worse.

Interesting article from Dr. J regarding tolerance

Author: welly321

Posted: Wed Nov 28, 2012 6:45 pm

Heres my thoughts. There are two major benefits to subs. Maintaining the physical side of addiction and also healing the mental side. When your taking suboxone as prescribed and staying away from old connects, the mental part of the addiciton is in remission. Obviously the physical part is still there. If someone on vicodin has such a crazy mental addiction that there willing to INCREASE the physical part just to fix the mental part then so be it. Let them do it. Its there choice. The prescribing dr should definitely explain that they will be increasing there physical addiction to opiates.

I mean to that person that said there tolerance was through the roof and they had to take 6 vics just to function. Lets just say that during my heroin use once i took 10 vicodin 7.5s and i was still sick. Even with this crazy tolerance, 8mg of sub is enough to keep me well. So using 8mg would increase your tolerance. If your ok with that then thats fine, its just doctors should be making the patients aware that the sub WILL be making there physical addiction worse.

RAN OUT 6 DAYS EARLY – HELP!!

Author: welly321

Posted: Wed Nov 28, 2012 7:02 pm

Roby wrote:
Since there is a ceiling effect and since it does not seem to matter what dose you take…why do doctors prescribe different mgs. for diff. people?? I still do not understand that.

This is a very good question. To be honest, I think a lot of it comes down to sublingual absorption. Some people absorb it better under the tongue. Someone taking 8mg could be absorbing the same amount as someone taking 16mg. Therefore the second person would not feel good on 8 even though they both get the same amount in there bloodstream.

Also the ceiling effect has been debated a lot. I think people used to say 2mg, now there saying its 4mg or even 8mg. Heck i’ve heard other people say its 32mg.

RAN OUT 6 DAYS EARLY – HELP!!

Author: welly321

Posted: Wed Nov 28, 2012 7:02 pm

Roby wrote:
Since there is a ceiling effect and since it does not seem to matter what dose you take…why do doctors prescribe different mgs. for diff. people?? I still do not understand that.

This is a very good question. To be honest, I think a lot of it comes down to sublingual absorption. Some people absorb it better under the tongue. Someone taking 8mg could be absorbing the same amount as someone taking 16mg. Therefore the second person would not feel good on 8 even though they both get the same amount in there bloodstream.

Also the ceiling effect has been debated a lot. I think people used to say 2mg, now there saying its 4mg or even 8mg. Heck i’ve heard other people say its 32mg.

Suboxone Taper Chart

Author: DaftNotStupid

Posted: Wed Nov 28, 2012 7:49 pm

I sent this as a private message to the chart’s author, but not getting a response after a few days, I thought I’d post it here too:

I like your taper model but I’ve found a problem with it. Using the default 37 hour half-life, it seems to work pretty well, but as the half-life is increased towards 72 – a frequently specified number, though I have also seen 37 to 72 mentioned as a range – the graph looks increasingly wrong. According to your model, while a single 1mg dose taken on day 1 decays to 0.5 after one day using a 24 hour half-life – what you would expect – it never decays at 48 hours, and grows to nearly 130Kg over 30 days at 72. This is obviously wrong – maybe someone else could check it out.

I have a few other comments and questions:

    How go you calculate the plasma levels from the actual dose? Have you thought of building in activation time into your model – I’ve seen numbers like 30-60 mins to full effectiveness. I’ve also seen mention to variable sloped decay.
    I can tell that you calculate the residual once per day, adding it to the next dose. That’s what I do in my spreadsheet model, as well. I was thinking about this approach, and wondered if the drug actually decays more quickly – if you calculate the half-life hourly rather than daily, you get slightly different results.
    It would be useful if you could specify a daily dose, instead of having to input each day separately. Being able to input or change each day’s dose will help people who want to see their levels when planning their tapers and final skips

J