Can the Chronic Administration of the Combination of Buprenorphine and Naloxone Block Dopaminergic Activity Causing Anti-reward and Relapse Potential?

We describe a mechanism whereby
chronic blockade of opiate receptors, in spite of only partial opiate agonist action, may ultimately block dopaminergic activity
causing anti-reward and relapse potential. While the direct comparison is not as yet available, toxicity to buprenorphine
can be found in the scientific literature. In considering our cautionary note in this commentary, we are cognizant that, to
date, this is what we have available, and until such a time when the real magic bullet is discovered, we will have to endure.
However, more than anything else this commentary should at least encourage the development of thoughtful new strategies to
target the specific brain regions responsible for relapse prevention.

Content Type Journal ArticlePages 1-19DOI 10.1007/s12035-011-82…

Can the Chronic Administration of the Combination of Buprenorphine and Naloxone Block Dopaminergic Activity Causing Anti-reward and Relapse Potential?

We describe a mechanism whereby
chronic blockade of opiate receptors, in spite of only partial opiate agonist action, may ultimately block dopaminergic activity
causing anti-reward and relapse potential. While the direct comparison is not as yet available, toxicity to buprenorphine
can be found in the scientific literature. In considering our cautionary note in this commentary, we are cognizant that, to
date, this is what we have available, and until such a time when the real magic bullet is discovered, we will have to endure.
However, more than anything else this commentary should at least encourage the development of thoughtful new strategies to
target the specific brain regions responsible for relapse prevention.

Content Type Journal ArticlePages 1-19DOI 10.1007/s12035-011-82…

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Suboxone Treatment Methadone Alternative : What is it?

What Is Suboxone Treatment (Buprenorphine Treatment)?

Suboxone Treatment Methadone Alternative

Suboxone Treatment Methadone Alternative

Suboxone treatment is another type of treatment for opioid addiction. It contains many similarities to methadone maintenance treatment. Opioid addicted patients usually relapse when trying to get off opioids such as oxycontin, heroin, vicodin, and other narcotics. Most addicts are unable to get through the withdrawal periods and don’t even last a several days.  Others get off, but at the first major stressor in their lives, they return to opioid use. Suboxone treatment can help stop this continuous relapse cycle.

Suboxone treatment will stop the dreaded opioid withdrawals. Since suboxone is another opioid, it will stop these withdrawals.  It also stops with cravings that an addict is going through.  Many addicts return to opioid use because of these creavings. Suboxone replaces the opioid in the patient’s system.  It has to be prescribed and monitored by a doctor.  If one is unable to get off opioids, it is better to be on one that is supervised, rather than getting it off the street with all the problems that come with doing this.  Eventually for many, the hope is to get off the suboxone treatment with the aid and medication from a physician. Some are able to get completely clean.

Why Suboxone Treatment ? Why Not Just Quit Suddenly

Getting on and staying on a narcotic such as methadone or suboxone works better than stopping suddenly.  When a patient is not having to be preoccupied with constant cravings they are able to focus on treatment.  When they don’t have to worry about losing their next job from being late getting high, they can focus on treatment. The point of suboxone treatment is to stabilize the person to get other areas of their life better first.

Opioid dependence destroys patient’s lives.  Heroin addicts frequently have legal problems.  Others are forging prescriptions from their doctor or they are doctor shopping. Not being able to hold down a job cause financial instability. Marriages split apart because of all the arguing and sneaking around. It is hard to pay attention to these areas of one’s life when a person is spending their time looking for drugs. Narcotics can found and taken by children. Relatives learn to distrust you.  People seek suboxone treatment to stop all these problems.

Is Suboxone Treatment a Hassle?

Suboxone treatment is much less of a hassle and more convenient than methadone maintenance treatment. The psychiatric evaluation is done in a private doctor’s clinic. Getting stabilized on suboxone can be done in a matter of hours or a few days. The nice thing about suboxone treatment, it that when one is finally doing well with the medication, they only need to go to their doctor’s office once per month to get the medication.  Those familiar with methadone maintenance understand that methadone clinics require going to the clinic daily.

Suboxone treatment is less public than methadone maintenance. They see their own doctor and are not around other substance abusing individuals. It is easier to get in and see a suboxone doctor than to get seen at a methadone clinic. During the treatment process, patients will go to their own therapist or to 12 step meetings for counseling. In most cases, they get to determine who they will see.  Suboxone is a tablet and is taken under the tongue.

In summary, suboxone treatment is a great alternative for opioid dependence.   Although not all patients talking methadone for addiction treatment will successfully be able to convert to suboxone, many can.  Now methadone is not the only medication that will work for opioid addiction. Be aware the generic name for suboxone is buprenorphine.

Suboxone Clinic Directory Find a Suboxone Physician Near You

Dr. Rich Senyszyn is a Board Certified Psychiatrist with licenses in Texas and Hawaii. He specializes in the treatment of opioid addiction with buprenorphine and runs a FREE locator service to find help with  Oxycontin including Suboxone treatment of oxycontin addiction. Suboxone Clinic in your area.
Dr. Rich has written more articles on the cost of oxycontin, buprenorphine (Suboxone) including frequently asked questions and a recent post : How do I find a Buprenorphine Doctor?

Compensation Effects on Clinical Trial Data Collection in Opioid-Dependent Young Adults.

Conclusion: These findings suggest that variations in the amount of compensation for completing assessments can differentially affect outcome measurements, depending on treatment group assignment. Scientific Significance: Adequate financial compensation may minimize bias when treatment condition is associated with differential dropout and may be a cost-effective way to reduce attrition. Moreover, active users may be more likely than non-active users to drop out if compensation is inadequate, especially in control groups or in groups who are not receiving active treatment.
PMID: 21936751 [PubMed – as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)

Compensation Effects on Clinical Trial Data Collection in Opioid-Dependent Young Adults.

Conclusion: These findings suggest that variations in the amount of compensation for completing assessments can differentially affect outcome measurements, depending on treatment group assignment. Scientific Significance: Adequate financial compensation may minimize bias when treatment condition is associated with differential dropout and may be a cost-effective way to reduce attrition. Moreover, active users may be more likely than non-active users to drop out if compensation is inadequate, especially in control groups or in groups who are not receiving active treatment.
PMID: 21936751 [PubMed – as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)

Compensation Effects on Clinical Trial Data Collection in Opioid-Dependent Young Adults.

Conclusion: These findings suggest that variations in the amount of compensation for completing assessments can differentially affect outcome measurements, depending on treatment group assignment. Scientific Significance: Adequate financial compensation may minimize bias when treatment condition is associated with differential dropout and may be a cost-effective way to reduce attrition. Moreover, active users may be more likely than non-active users to drop out if compensation is inadequate, especially in control groups or in groups who are not receiving active treatment.
PMID: 21936751 [PubMed – as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)

Escitalopram is associated with reductions in pain severity and pain interference in opioid dependent patients with depressive symptoms

Summary: Use of escitalopram 10mg daily compared to placebo resulted in decreased pain severity and interference in a sample of opioid-dependent patients with depressive symptoms.Abstract: Pain is common among opioid-dependent patients, yet pharmacologic strategies are limited. The aim of this study was to explore whether escitalopram, a selective serotonin reuptake inhibitor, was associated with reductions in pain. The study used longitudinal data from a randomized, controlled trial that evaluated the effects of escitalopram on treatment retention in patients with depressive symptoms who were initiating buprenorphine/naloxone for treatment of opioid dependence. Participants were randomized to receive escitalopram 10mg or placebo daily. Changes in pain severity, pain interference, and depr…