Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults

Opioid use disorders are considered a serious public health problem that is associated with increased morbidity and mortality (Degenhardt et al., 2014; Im et al., 2015; Larney et al., 2015; Yokell et al., 2014). While the recent rate of heroin use in the general population has remained relatively stable, with perhaps even some slight reduction in the use of prescription opioids among 12th graders in 2014 (Johnston et al., 2015), the last-year prevalence of heroin (∼0.7%, MTF) and prescription opioid use (8.8%, NSDUH) among young adults is disproportionately elevated (Johnston et al., 2014; SAMHSA, 2014). (Source: Drug and Alcohol Dependence)