A Prospective, Randomized, Multicenter Acceptability And Safety Study Of Direct Buprenorphine/Naloxone Induction In Heroin�Dependent Individuals

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Conclusions:  Direct BNX induction was a safe and effective strategy for maintenance treatment of opioid dependence. Response to high�dose direct BNX induction appears to be similar to indirect BPN�to�BNX induction and was not associated with reports of intravenous BNX misuse. (Source: Addiction)