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WASHINGTON – The head of a nonprofit organization that represents drug courts lobbied the U.S. Department of Health and Human Services against increasing access to a key addiction treatment. In an Aug. 19, 2014, letter obtained by The Huffington Post through an open records request, West Huddleston, the then-CEO of the National Association of Drug Court Professionals, wrote HHS Secretary Sylvia Mathews Burwell and urged her to keep strict caps on the number of opioid addicts doctors can treat with buprenorphine. Use of the medication along with counseling, known as medication-assisted treatment, is considered by public health officials to give opioid addicts the best chance at a recovery. But many drug court judges have opposed the treatment, insisting defendants go cold turkey …

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W-18
Last August, Canadian police seized 110 illegal fentanyl pills at a home in Alberta province. Yesterday, Global News reported that some of the pills have tested positive for an extremely potent opioid called W-18.
This is certainly a disturbing development, since W-18 is a μ-receptor agonist 100 times more potent than fentanyl. According to B.C. Centre for Disease Control, W-18 is one of a series of 32 synthetic opioids discovered in the 1980s at the University of Alberta. W1 thru W19 are pure μ-receptor agonists; W20 thru W32 are agonist-antagonists (as is buprenorphine.)  W-18 seems to be the most powerful agonist of the group.
The ‘W’ compounds have never been used clinically, and there has been virtually no scientific study of their actions, adverse effects, or reve…

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Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence

February 1, 2016

Objectives: The aim of the study was to evaluate buprenorphine-naloxone effects on the QTc in youth with opioid dependence. Buprenorphine is a partial agonist that is an effective treatment for opioid dependence. Compared with methadone, it has a lower risk of QTc prolongation in adults, but is less studied in the youth. It may also […]

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Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic.

January 30, 2016

CONCLUSIONS: The core components of our approach-biopsychosocial assessment and multimodal treatment planning with an emphasis on promoting functional goals and safety using clear communication and a patient-centered stance-should guide providers in the management of similar clinical scenarios. More evidence is needed to definitively guide specific interventions and points of clinical equipoise. PMID: 26818474 [PubMed – […]

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Why are doctors writing opioid prescriptions — even after an overdose?

January 28, 2016

A group of researchers at Boston Medical Center recently looked at nearly 3,000 patients who had survived an opioid-related overdose between 2000 and 2012. According to their recently published study, over 90% of these patients continued to receive opioid medications from doctors — even after their overdose. Given the soaring numbers of opioid-related overdose deaths […]

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Total Joint Arthroplasty in Patients Taking Methadone or Suboxone Preoperatively for Prior Heroin Addiction: A Prospective Matched Cohort Study

January 27, 2016

Preoperative narcotic use has been associated with poor outcomes following total joint arthroplasty (TJA). The purpose of this study is to compare clinical outcomes of patients undergoing elective TJA while concurrently being treated with methadone or buprenorphine/naloxone for prior heroin addiction to a matched control group. (Source: The Journal of Arthroplasty)

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Overdose Reversal Drug Now Available To Every U.S. High School Free Of Charge

January 26, 2016

Any high school in the U.S. that wants to carry an emergency opioid overdose reversal kit will now be able to get one free of charge, thanks to a new initiative announced Monday by the Clinton Foundation and the drug’s manufacturer. Adapt Pharma, manufacturers of a nasal-spray form of naloxone, also known as Narcan, has […]

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Akorn Launches Buprenorphine/Naloxone Sublingual Tablets and Tobramycin Injection

January 19, 2016

LAKE FOREST, Ill., Jan. 19, 2016 — (Healthcare Sales & Marketing Network) — Akorn, Inc. (AKRX), a leading specialty generic pharmaceutical company, today announced that it has launched Buprenorphine and Naloxone Sublingual Tablets CIII in 2mg/0.5mg and 8… Biopharmaceuticals, Generics, Product LaunchAkorn, Buprenorphine, Naloxone, Tobramycin (Source: HSMN NewsFeed)

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Malmö Treatment Referral and Intervention Study (MATRIS)—effective referral from syringe exchange to treatment for heroin dependence: a pilot randomized controlled trial

January 12, 2016

ConclusionsA randomized controlled trial in a syringe exchange programme showed no evidence that a strength‐based case management intervention improved attendance for treatment over referral alone. Attendance rates were high in both groups. (Source: Addiction) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

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Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder

January 12, 2016

This study demonstrated that RBP-6000 at a 300 mg dose provides durable and potent blockade of the subjective effects and reinforcing efficacy of hydromorphone in subjects with moderate or severe opioid use disorder. (Source: Journal of Clinical Psychopharmacology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents […]

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