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The high prevalence of interrelated problems with opioid use disorder, injection drug use (IDU), and HIV/AIDS in Malaysia has led to the scale-up of public health approaches, including opioid agonist maintenance treatment with buprenorphine or methadone. Malaysia has more than 300,000 registered people who use drugs (PWUD)-approximately 1.1% of its population of about 30 million-and an estimated 170,000 people who inject drugs (PWID; Nazar and Ahlam, 2007; Global AIDS Response, 2012), with heroin continuing to be the drug most frequently injected. (Source: Drug and Alcohol Dependence)

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Opinion statement
Prescription opioid misuse has been a significant epidemic during the past decade. Formulations of prescription opioids with different mechanisms of abuse-deterrence have been developed or are currently under development. Given that these medications are substantially more difficult to use in an illicit fashion and minimize the potential for euphoria and/or create an aversive experience when over-ingested, they represent an important next step in pharmacological innovation. Immediate decreases in nonmedical use and in associated overdose mortality and adverse events have been observed after a highly abused opioid, OxyContin, was changed into an abuse-deterrent formulation. However, this reduction in OxyContin use may have simply shifted the drug of choice towards…

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Examining the factor structure of the Clinical Opiate Withdrawal Scale: A secondary data analysis from the National Drug Abuse Treatment Clinical Trials Network (CTN) 0003

April 9, 2015

Opiate withdrawal scales were developed to examine the patient’s physical dependence and physiological readiness prior to methadone or buprenorphine induction, and to compare treatments for withdrawal (Wesson and Ling, 2003). The Clinical Opiate Withdrawal Scale (COWS; Wesson and Ling, 2003) is a common measure used to assess withdrawal in clinical trials and practice, and consists […]

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Diversion of opioid maintenance treatment medications and predictors for diversion among Finnish maintenance treatment patients

March 31, 2015

Diversion and abuse of the medications used in opioid maintenance treatment (OMT) methadone (MET), mono-buprenorphine (BUP) and buprenorphine-naloxone (BNX) have been documented in countries around the world, for example in France (Auriacombe, Fatseas, Dubernet, Daulouede, & Tignol, 2004; Nordmann et al., 2012; Obadia, Perrin, Feroni, Vlahov, & Moatti, 2001; Roux et al., 2008a; Roux et […]

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Novel Buccal Film Formulation of Buprenorphine-Naloxone for the Maintenance Treatment of Opioid Dependence: A 12-Week Conversion Study.

March 26, 2015

Authors: Sullivan JG, Webster L Abstract PURPOSE: The purpose of this study was to provide a preliminary assessment of the safety, tolerability, symptom control, and acceptability of buprenorphine-naloxone buccal film (BBN) for the maintenance treatment of opioid dependence in patients converted from buprenorphine-naloxone sublingual tablet or film (SLBN), as well as to determine the conversion […]

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Zubsolv (Buprenorphine and Naloxone Sublingual Tablets) – updated on RxList

March 25, 2015

(Source: RxList – New and Updated Drug Monographs) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

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Non-controlled and over-the-counter drugs of abuse

March 24, 2015

  2.5 out of 5 stars Abuse of Medications That Theoretically Are Without Abuse Potential. Reeves RR et al. South Med J 2015 Mar;108:151-157. Abstract This review of noncontrolled prescription and over-the-counter drugs that can be and have been abused for non-medical or recreational purposes is rather sketchy and anecdotal (as the authors admit,) but nevertheless […]

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Expanding Substance Use Treatment Options for HIV Prevention With Buprenorphine–Naloxone: HIV Prevention Trials Network 058

March 12, 2015

Conclusions: Participants receiving BUP/NX 3 times weekly were more likely to reduce opioid injection while on active treatment. Both treatment strategies were considered safe and associated with reductions in injection-related risk behavior. These data support the use of thrice-weekly BUP/NX as a way to reduce exposure to HIV risk. Continued access to BUP/NX may be […]

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BUPRENORPHINE HCL AND NALOXONE HCL (Buprenorphine And Naloxone) Tablet [Amneal Pharmaceuticals Of New York, LLC]

March 10, 2015

Updated Date: Mar 10, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

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Buprenorphine-Naloxone treatment of prescription opioid abuse: does past performance predict future results?

March 7, 2015

Authors: Langleben DD Abstract Misuse of prescription opioids is a national public health problem: In the United States, according to the 2012 National Survey on Drug Use and Health, 4.5 million, or 1.7%, of persons aged 12 or older reported current nonmedical use of pain relievers, and 335,000 reported currently using heroin. This is an […]

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