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Abstract
In spite of the clinical utility of buprenorphine, parenteral abuse of this medication has been reported in several laboratory investigations and in the real world. Studies have demonstrated lower abuse liability of the buprenorphine/naloxone combination relative to buprenorphine alone. However, clinical research has not yet examined the utility of the combined formulation to deter intranasal use in a buprenorphine‐maintained population. Heroin‐using volunteers (n = 12) lived in the hospital for 8–9 weeks and were maintained on each of three sublingual buprenorphine doses (2, 8, 24 mg). Under each maintenance dose, participants completed laboratory sessions during which the reinforcing and subjective effects of intranasal doses of buprenorphine (8, 16 mg), buprenorph…

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CONCLUSION: In a chronic pain patient continued on Suboxone perioperatively, significant improvement in control of postoperative pain was observed following tapered doses, and eventually her use of Suboxone was discontinued. This case highlights the potential for opioid receptor blockade by Suboxone, which can interfere with acute pain management.
PMID: 24985936 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

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Naltrexone implant treatment for buprenorphine dependence – Mauritian case series

July 1, 2014

Although substitution therapy with opiate agonist treatments such as methadone and buprenorphine has resulted in a reduction of illicit drug use related harm, such treatment has also resulted in severe problems in some countries where opioid-dependent individuals now inject illicitly sold buprenorphine or buprenorphine-naloxone instead of heroin. There is no approved treatment for buprenorphine dependence. […]

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BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE DIHYDRATE Tablet [Roxane Laboratories, Inc.]

June 30, 2014

Updated Date: Jun 30, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

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Positive Results With Combo Tx for Opioid Dependence Positive Results With Combo Tx for Opioid Dependence

June 24, 2014

Orexo AB announced new topline results of 2 clinical trials with a combination of buprenorphine and naloxone for buprenorphine induction and plans to pursue approval of an expanded label in the US. Medscape Medical News (Source: Medscape Medical News Headlines) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

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Bunavail (Buprenorphine and Naloxone Buccal Film) – updated on RxList

June 20, 2014

(Source: RxList – New and Updated Drug Monographs) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

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SUBOXONE (Buprenorphine Hydrochloride, Naloxone Hydrochloride) Film, Soluble [A-S Medication Solutions LLC]

June 13, 2014

Updated Date: Jun 13, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BUPRENORPHINE HCL AND NALOXONE HCL (Buprenorphine And Naloxone) Tablet [A-S Medication Solutions LLC]

June 13, 2014

Updated Date: Jun 13, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

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BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE DIHYDRATE Tablet [Actavis Elizabeth LLC]

June 6, 2014

Updated Date: Jun 6, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

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Potentiation of the effect of buprenorphine/naloxone with gabapentin or quetiapine.

May 31, 2014

Authors: Reeves RR, Ladner ME PMID: 24880512 [PubMed - in process] (Source: The American Journal of Psychiatry)

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