Effect of Steady-State Faldaprevir on the Pharmacokinetics of Steady-State Methadone and Buprenorphine/Naloxone in Subjects on Stable Addiction Management Therapy.

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In conclusion, faldaprevir 240 mg QD can be coadministered with methadone or buprenorphine/naloxone without dose adjustment, although given the relatively narrow therapeutic windows of these agents, monitoring for opiate overdose and withdrawal may still be appropriate Registered at ClinicalTrials.gov registration number: NCT01637922.
PMID: 25385094 [PubMed – as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

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