A Prospective, Randomized, Multicenter Acceptability And Safety Study Of Direct Buprenorphine/Naloxone Induction In Heroin‐Dependent Individuals

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Conclusions:  Direct BNX induction was a safe and effective strategy for maintenance treatment of opioid dependence. Response to high‐dose direct BNX induction appears to be similar to indirect BPN‐to‐BNX induction and was not associated with reports of intravenous BNX misuse. (Source: Addiction)