How quickly does tolerance develop?

Posted on by

Author: tearj3rker

Posted: Sat Mar 03, 2012 3:26 am

I found something that may be interesting:

Quote:
At low doses buprenorphine in humans produces morphine like subjective, physiological and behavioural
effects. These include analgesia, sedation, pupillary constriction and euphoria. When the dose of
buprenorphine is increased, the intensity of its actions does not seem to exceed that achieved with 30-60 mg
morphine. When given sublingually, morphine like subjective effects (euphoria) reached a ceiling at about 8-
16 mg.

So according to this study the ceiling effect for subjective euphoria is around 8-16mg – likely meaning dose response begins to curve and plateaus in the 8-16mg range.

The only reason I can think people may be prescribed over 16mg would be to facilitate once daily dosing, so trough serum levels are high enough to hold each individual, esp those with faster metabolisms.

How quickly does tolerance develop?

Posted on by

Author: tearj3rker

Posted: Sat Mar 03, 2012 3:26 am

I found something that may be interesting:

Quote:
At low doses buprenorphine in humans produces morphine like subjective, physiological and behavioural
effects. These include analgesia, sedation, pupillary constriction and euphoria. When the dose of
buprenorphine is increased, the intensity of its actions does not seem to exceed that achieved with 30-60 mg
morphine. When given sublingually, morphine like subjective effects (euphoria) reached a ceiling at about 8-
16 mg.

So according to this study the ceiling effect for subjective euphoria is around 8-16mg – likely meaning dose response begins to curve and plateaus in the 8-16mg range.

The only reason I can think people may be prescribed over 16mg would be to facilitate once daily dosing, so trough serum levels are high enough to hold each individual, esp those with faster metabolisms.