Author: tearj3rker

Posted: Sat Feb 04, 2012 11:04 pm

I’ve found a happy medium for now.

For me, the problem was worse with once daily dosing. Twice daily reduced the problem a bit. I get the feeling that for me, higher doses don’t increase the half-life as much as it should. If I dosed once a day, I’d wake up in the morning a bit sweaty with the kicks, and hate the thought of getting out of the shower into the cold. With twice daily, the issue isn’t as noticeable. The other thing that really helped was figuring out which medications caused the problems, and changing them accordingly. It seemed anti-depressants (Cymbalta / Effexor / Pristiq) and Epilim / Depakote played a big role. But a lot of other medications can do it to lesser degrees.

For me, I can get by on a lower dose with twice daily dosing, ie 12mg. When I dose once daily, I need 16+mg to get 24 hour cover.